DESIGN AND SYNTHESIS OF LACTAMS DERIVED FROM MUCOCHLORIC AND MUCOBROMIC ACIDS AS PSEUDOMONAS AERUGINOSA QUORUM SENSING INHIBITORS

Design and Synthesis of Lactams Derived from Mucochloric and Mucobromic Acids as Pseudomonas aeruginosa Quorum Sensing Inhibitors

Bacterial infections, particularly hospital-acquired infections caused by Pseudomonas aeruginosa, have become a global threat with a high mortality rate.Gram-negative bacteria including P.aeruginosa employ N-acyl homoserine lactones (AHLs) as chemical signals to regulate the expression of pathogenic phenotypes through a mechanism called quorum sens

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